Description

4-(2,2,2-Trifluoroethoxy)Benzene-1-Sulfonyl Chloride CAS NO 954369-08-5 is a high-purity, specialized sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in introducing the sulfonyl chloride functional group, which is essential for constructing sulfonamides and other complex molecules, while the trifluoroethoxy moiety offers unique electronic and steric properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing custom intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the sulfonamide group contributes to biological activity.
• Material Science Research: Employed in creating specialized monomers or polymers with specific surface properties or chemical resistance.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or other biomolecules to study biological pathways.
• Custom Fine Chemical Production: Serves as a versatile starting material for contract research organizations (CROs) and CDMOs to fulfill bespoke synthesis projects.

Basic Information

Product Name	4-(2,2,2-Trifluoroethoxy)Benzene-1-Sulfonyl Chloride
CAS No.	954369-08-5
Molecular Formula	C8H6ClF3O3S
Molecular Weight	274.64 g/mol
Synonyms	1-(Trifluoroethoxy)-4-(chlorosulfonyl)benzene; p-(2,2,2-Trifluoroethoxy)benzenesulfonyl chloride; 4-(Trifluoroethoxy)benzenesulfonyl chloride; 4-(2,2,2-Trifluoroethoxy)phenylsulfonyl chloride; Benzenesulfonyl chloride, 4-(2,2,2-trifluoroethoxy)-; 954369-08-5; TFEOBS-Cl
EINECS	Contact for details

Quality Control

Our 4-(2,2,2-Trifluoroethoxy)Benzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.