Description

8-(Difluoromethoxy)-1,2,3,4-Tetrahydroquinoline is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique difluoromethoxy moiety, which can enhance metabolic stability and modulate physicochemical properties in target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can improve biological activity and environmental persistence.
• Advanced Material Precursor: Serves as a specialized monomer or building block for developing functional polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probe: Employed in the synthesis of molecular probes and labeled compounds for studying biochemical pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke fluorinated compounds for clients.
• Academic & Institutional Research: Utilized in university and institutional laboratories for methodological development in fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	8-(Difluoromethoxy)-1,2,3,4-Tetrahydroquinoline
CAS No.	953735-66-5
Molecular Formula	C10H11F2NO
Molecular Weight	199.20 g/mol
Synonyms	1,2,3,4-Tetrahydro-8-(difluoromethoxy)quinoline; 8-(Difluoromethoxy)-1,2,3,4-tetrahydroquinoline; Quinoline, 1,2,3,4-tetrahydro-8-(difluoromethoxy)-; 8-(Difluoromethoxy)-1,2,3,4-tetrahydro-quinoline; 8-Difluoromethoxy-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 8-(Difluoromethoxy)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.