Description

10-Hydroxycamptothecin Acetate is a semi-synthetic derivative of the potent natural topoisomerase I inhibitor, camptothecin. This compound is valued for its enhanced solubility profile and serves as a critical intermediate in the development of novel anticancer therapeutics. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the synthesis of advanced drug candidates and prodrugs targeting various solid tumors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of next-generation camptothecin analogs and prodrugs with improved pharmacokinetic properties.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate mechanisms of topoisomerase I inhibition and antitumor efficacy.
• Drug Discovery & Development: Serves as a versatile scaffold for medicinal chemistry optimization programs aimed at reducing toxicity and enhancing therapeutic windows.
• Biochemical Reagent: Employed in enzymatic and cellular assays to study DNA replication, repair mechanisms, and apoptosis induction.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and anticancer agent development.

Basic Information

Item	Detail
Product Name	10-Hydroxycamptothecin Acetate
CAS No.	951770-22-2
Molecular Formula	C22H18N2O6
Molecular Weight	406.39 g/mol
Synonyms	10-HCPT Acetate; 10-Hydroxycamptothecin 10-Acetate; (S)-10-Acetoxycamptothecin; 10-O-Acetylcamptothecin; Camptothecin, 10-hydroxy-, acetate (ester); 10-Acetoxy-20(S)-camptothecin; 10-Hydroxycamptothecin acetate ester
EINECS	Contact for details

Quality Control

Our 10-Hydroxycamptothecin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.