Description

2-Chloro-5-Fluoropyridine-4-Boronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value proposition lies in enabling the precise construction of complex heterocyclic molecules through efficient cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and advanced materials.

Application

This versatile boronic acid pinacol ester is a key intermediate in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: A crucial building block for Suzuki-Miyaura cross-coupling reactions in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used to construct complex pyridine-based scaffolds for next-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Precursor: Employed in the development of organic electronic materials, such as ligands for OLEDs and charge-transport materials, due to its functionalized pyridine core.
• Chemical Biology Probe Development: Serves as a handle for bioconjugation and the creation of molecular probes for studying biological systems and target engagement.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated bidentate and polydentate ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Item	Details
Product Name	2-Chloro-5-Fluoropyridine-4-Boronic Acid
CAS No.	951677-47-7
Molecular Formula	C5H4BClFNO2
Molecular Weight	174.36 g/mol
Synonyms	(2-Chloro-5-fluoropyridin-4-yl)boronic acid; 2-Chloro-5-fluoro-4-pyridineboronic acid; 4-Borono-2-chloro-5-fluoropyridine; 951677-47-7; 2-Chloro-5-fluoropyridine-4-boronic acid pinacol ester (common derivative); 5-Fluoro-2-chloropyridine-4-boronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyridine-4-Boronic Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.