Description

2-Chloro-5-(Chloromethyl)-3-Fluoropyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its dual reactive sites, enabling selective functionalization to create complex molecular architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the pyridine core for enhanced bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its halogenated structure.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Item	Details
Product Name	2-Chloro-5-(Chloromethyl)-3-Fluoropyridine
CAS No.	951652-82-7
Molecular Formula	C6H4Cl2FN
Molecular Weight	180.01 g/mol
Synonyms	3-Fluoro-2-chloro-5-(chloromethyl)pyridine; 2-Chloro-3-fluoro-5-(chloromethyl)pyridine; 5-(Chloromethyl)-2-chloro-3-fluoropyridine; (2-Chloro-3-fluoropyridin-5-yl)methyl chloride; Pyridine, 2-chloro-5-(chloromethyl)-3-fluoro-; 951652-82-7
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Chloromethyl)-3-Fluoropyridine is manufactured under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and impurity profiles. Our quality commitment ensures material consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.