Description

1-Bromo-5-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromo, nitro, methoxy, and trifluoromethyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the nitro and bromo groups serve as handles for further functionalization.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for method development and the exploration of new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	1-Bromo-5-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene
CAS No.	951231-87-1
Molecular Formula	C9H5BrF3NO3
Molecular Weight	312.04 g/mol
Synonyms	4-Bromo-2-Methoxy-5-Nitrobenzotrifluoride; 2-Methoxy-5-nitro-4-(trifluoromethyl)bromobenzene; 5-Bromo-2-methoxy-α,α,α-trifluoro-p-nitrotoluene; 1-Bromo-5-methoxy-2-nitro-4-(trifluoromethyl)benzene; Benzene, 1-bromo-5-methoxy-2-nitro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2-methoxy-5-nitro-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent lot-to-lot quality suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. This material is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.