Description

1-Chloro-2,4-Difluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the benzene ring, enabling selective functionalization and serving as a key precursor for complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and specialty intermediates.

Application

• Pharmaceutical Intermediate: A critical starting material for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl or chlorophenyl motifs.
• Agrochemical Synthesis: Serves as a key precursor in the manufacture of herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Liquid Crystal & OLED Material Precursor: Used in the production of specialty chemicals for electronic displays and organic light-emitting diodes due to its stable aromatic core and halogen substituents.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on aromatic systems in medicinal and materials chemistry.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where halogen atoms influence color and stability properties.

Basic Information

Product Name	1-Chloro-2,4-Difluorobenzene
CAS No.	1435-44-5
Molecular Formula	C6H3ClF2
Molecular Weight	148.54 g/mol
Synonyms	2,4-Difluorochlorobenzene; 2,4-Difluoro-1-chlorobenzene; 1-Chloro-2,4-difluorobenzene; 2,4-Difluorophenyl chloride; Benzene, 1-chloro-2,4-difluoro-; 2,4-DFCB; 2,4-Difluorochlorobenzol
EINECS	215-858-4

Quality Control

Our 1-Chloro-2,4-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%
Density (at 20°C)	~1.40 g/mL
Boiling Point	~142-144 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.