Description

1-Bromo-2,3,4,6-Tetrafluorobenzene is a versatile fluorinated aromatic building block, valued for its unique combination of bromine and fluorine substituents which impart significant reactivity and stability. This compound is essential for introducing the tetrafluorophenylene moiety into complex molecular architectures, enabling the synthesis of advanced materials and pharmaceuticals. It is primarily sought by researchers and manufacturers in the agrochemical, pharmaceutical, and specialty chemical industries for applications in cross-coupling reactions and as a precursor for liquid crystals and electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides where the fluorine atoms improve lipophilicity and biological activity.
• Material Science: Serves as a monomer or building block for the production of specialty polymers, liquid crystals, and organic semiconductors for electronic applications.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel fluorinated compounds.
• Dye and Pigment Industry: Acts as an intermediate in the synthesis of fluorinated dyes and pigments that offer superior light fastness and chemical resistance.

Basic Information

Product Name	1-Bromo-2,3,4,6-Tetrafluorobenzene
CAS No.	1559-86-0
Molecular Formula	C6HBrF4
Molecular Weight	226.97 g/mol
Synonyms	2,3,4,6-Tetrafluorobromobenzene; Bromotetrafluorobenzene; 1-Bromo-2,3,4,6-tetrafluorobenzol; Benzene, 1-bromo-2,3,4,6-tetrafluoro-; BTFB; NSC 88249; 2,3,4,6-Tetrafluoro-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,3,4,6-Tetrafluorobenzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We are committed to supplying material suitable for demanding applications in research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (at 20°C)	~1.85 g/mL
Refractive Index (n20D)	~1.45

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.