Description

4-(Difluoromethoxy)Toluene is a versatile fluorinated aromatic building block with the CAS number 1583-83-1. This compound is valued for its unique difluoromethoxy group, which imparts enhanced metabolic stability and lipophilicity, making it a critical intermediate in advanced synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients. Its properties also make it suitable for applications in material science and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoromethoxy moiety improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorine into polymer chains, enhancing chemical resistance, thermal stability, and surface properties of specialty plastics.
• Organic Synthesis Reagent: A valuable reagent in cross-coupling reactions and as a protecting group alternative in complex multi-step synthetic routes.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new fluorination methodologies and creating compound libraries.

Basic Information

Product Name	4-(Difluoromethoxy)Toluene
CAS No.	1583-83-1
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	1-Methyl-4-(difluoromethoxy)benzene; p-(Difluoromethoxy)toluene; 4-Methyl(difluoromethoxy)benzene; Difluoromethyl 4-methylphenyl ether; α,α-Difluoro-p-cresyl methyl ether; p-Tolyl difluoromethyl ether; 1583-83-1; Benzene, 1-methyl-4-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Toluene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and quantify impurities. Certificates of Analysis (COA) detailing purity, assay, and specific impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and oxidizing agents. Due to its highly volatile nature, ensure containers are securely sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density	~1.15 g/cm³ at 20°C
Boiling Point	~180-185°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.