Description

7,11-Diethyl-10-Hydroxycamptothecin is a synthetic derivative of the potent natural alkaloid camptothecin, engineered for enhanced pharmacological properties. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel topoisomerase I inhibitor-based chemotherapeutics. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and biotechnology firms engaged in oncology drug discovery and advanced cancer treatment formulations.

Application

• Oncology Drug Discovery: Serves as a key scaffold and intermediate for synthesizing next-generation topoisomerase I inhibitors with improved solubility and reduced toxicity profiles.
• Pharmaceutical R&D: Used in preclinical and clinical research to study structure-activity relationships (SAR) and develop new chemotherapeutic agents targeting various solid tumors.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and bioanalytical laboratories for method development and validation.
• Biochemical Research: Utilized in mechanistic studies to investigate DNA replication, cell cycle arrest, and apoptosis induction in cancer cell lines.
• Fine Chemical Synthesis: Acts as a sophisticated building block for the custom synthesis of targeted drug conjugates and prodrugs.
• Academic Research: Supports university and institutional research programs focused on medicinal chemistry and anticancer drug mechanisms.

Basic Information

Product Name	7,11-Diethyl-10-Hydroxycamptothecin
CAS No.	947687-01-6
Molecular Formula	C24H24N2O5
Molecular Weight	420.46 g/mol
Synonyms	10-Hydroxy-7,11-diethylcamptothecin; 7,11-Diethyl-10-hydroxy-20(S)-camptothecin; DE-10H-CPT; SN-38 Diethyl Analog; (S)-10-Hydroxy-7,11-diethylcamptothecin; 20(S)-7,11-Diethyl-10-hydroxycamptothecin; Camptothecin, 7,11-diethyl-10-hydroxy-
EINECS	Contact for details

Quality Control

Our 7,11-Diethyl-10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.