Description

4-Trifluoromethyl-Pyridine-3-Boronic Acid CAS NO 947533-39-3 is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules containing the versatile pyridine and trifluoromethyl motifs.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring the trifluoromethylpyridine pharmacophore.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the pyridine core offers specific biological activity.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boronic acid partner for coupling with various aryl/heteroaryl halides to form biaryl and heterobiaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and advanced polymers.
• Chemical Biology & Medicinal Chemistry: Utilized in fragment-based drug discovery and for creating molecular probes and diagnostic agents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses producing specialized fine chemicals for client projects.

Basic Information

Product Name	4-Trifluoromethyl-Pyridine-3-Boronic Acid
CAS No.	947533-39-3
Molecular Formula	C7H5BF3NO2
Molecular Weight	190.93 g/mol
Synonyms	3-Pyridineboronic acid, 4-(trifluoromethyl)-; (4-(Trifluoromethyl)pyridin-3-yl)boronic acid; 4-(Trifluoromethyl)-3-pyridinylboronic acid; 4-Trifluoromethyl-3-pyridineboronic acid; 3-Borono-4-(trifluoromethyl)pyridine; 947533-39-3; 4-CF3-Pyridine-3-Boronic Acid
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-Pyridine-3-Boronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.