Description

Vincristine n-Oxide is a chemically modified derivative of the potent antineoplastic agent vincristine. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a precursor or intermediate in the synthesis of novel chemotherapeutic agents. It serves as a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on oncology drug discovery and advanced therapeutic formulation.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the research and production of novel vinca alkaloid derivatives and related anticancer compounds.
• Oncology Research: Utilized in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action of modified vinca alkaloids.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Drug Discovery & Development: Employed in medicinal chemistry programs aimed at developing new chemotherapeutic agents with potentially improved efficacy or reduced neurotoxicity profiles.
• Academic & Institutional Research: Used in university and research institute settings for fundamental studies in cancer biology and organic synthesis.

Basic Information

Product Name	Vincristine n-Oxide
CAS No.	947527-73-3
Molecular Formula	C46H58N4O12
Molecular Weight	851.0 g/mol (approx.)
Synonyms	22-Oxovincristine; Leurocristine N-Oxide; Vincristine N-Oxide; Vincristine 22-Oxide; 22-Oxo-leurocristine; (3aR,3a1R,4R,5S,5aR,10bR)-Methyl 4-acetoxy-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate 22-Oxide
EINECS	Contact for details

Quality Control

Our Vincristine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.