Description

1-(2,2,2-Trifluoroacetyl)-1,2,3,4-Tetrahydroquinoline-6-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate designed for advanced synthesis. This compound is critical for introducing both the sulfonyl chloride and trifluoroacetyl-protected amine moieties into target molecules, enabling precise structural modifications. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including protease inhibitors and herbicides.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing bioactive molecules, particularly protease inhibitors and other small-molecule drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with enhanced efficacy.
• Chemical Biology & Proteomics: Serves as a reagent for labeling and modifying proteins or peptides to study enzyme activity and interactions.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific functional groups.
• Custom Synthesis & Contract Manufacturing: A crucial starting material for fine chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	1-(2,2,2-Trifluoroacetyl)-1,2,3,4-Tetrahydroquinoline-6-Sulfonyl Chloride
CAS No.	947498-97-7
Molecular Formula	C11H9ClF3NO3S
Molecular Weight	327.71 g/mol
Synonyms	6-(Chlorosulfonyl)-1-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-1-(2,2,2-trifluoroacetyl)-6-quinolinesulfonyl chloride; N-Trifluoroacetyl-1,2,3,4-tetrahydroquinoline-6-sulfonyl chloride; 1-(Trifluoroacetyl)-1,2,3,4-tetrahydroquinoline-6-sulfonyl chloride; 6-Quinolinesulfonyl chloride, 1,2,3,4-tetrahydro-1-(2,2,2-trifluoroacetyl)-; TETQ-6-SCl
EINECS	Contact for details

Quality Control

Our production of 1-(2,2,2-Trifluoroacetyl)-1,2,3,4-Tetrahydroquinoline-6-Sulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is analyzed using advanced techniques like HPLC, NMR, and mass spectrometry to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.