Description

Glucocorticoid Resistance Inhibitor CAS NO 947018-15-7 is a potent, small-molecule compound specifically designed to modulate glucocorticoid receptor signaling pathways. This compound is critical for research and development in overcoming therapeutic resistance in inflammatory and oncological contexts. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on endocrinology, oncology, and autoimmune disease research.

Application

• Research Tool for Glucocorticoid Resistance Mechanisms: Fundamental biochemical and cellular research to study the pathways and molecular basis of resistance to glucocorticoid therapies.
• Oncology Research: Investigation into overcoming glucocorticoid resistance in hematologic malignancies such as leukemia and lymphoma to improve therapeutic outcomes.
• Inflammatory & Autoimmune Disease Research: Pre-clinical studies aimed at restoring sensitivity to glucocorticoids in conditions like rheumatoid arthritis, asthma, and lupus.
• Drug Discovery & Development: Serving as a lead compound or reference standard in high-throughput screening and the development of novel adjuvant therapies.
• Endocrinology Studies: Exploration of adrenal function and stress response systems where glucocorticoid signaling is dysregulated.
• Molecular Biology Applications: Used in assays to investigate gene expression regulation mediated by the glucocorticoid receptor.

Basic Information

Product Name	Glucocorticoid Resistance Inhibitor
CAS No.	947018-15-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GR Inhibitor; Glucocorticoid Receptor Resistance Modulator; CAS 947018-15-7; 947018-15-7; Glucocorticoid Sensitizer; Steroid Resistance Inhibitor; [Chemical name based on IUPAC to be confirmed]; Potential research code names (e.g., GRi-XXX series)
EINECS	Contact for details

Quality Control

Our Glucocorticoid Resistance Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure high purity and batch-to-batch consistency suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.