Description

6-(Difluoromethyl)Nicotinaldehyde is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an aldehyde and a difluoromethyl group on the pyridine ring, makes it indispensable for creating novel compounds with tailored properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Development: Serves as a versatile building block for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, such as liquid crystals and electronic chemicals.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorination on molecular reactivity and bioactivity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	6-(Difluoromethyl)Nicotinaldehyde
CAS No.	946578-32-1
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	6-(Difluoromethyl)pyridine-3-carboxaldehyde; 3-Pyridinecarboxaldehyde, 6-(difluoromethyl)-; Nicotinaldehyde, 6-(difluoromethyl)-; 6-Difluoromethylnicotinaldehyde; Pyridine-3-carboxaldehyde, 6-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Nicotinaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.