Description

Ontuxizumab is a high-purity, recombinant monoclonal antibody designed for targeted therapeutic applications. This product is critical for research and development in advanced biopharmaceuticals, offering a reliable and well-characterized biological agent. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and clinical diagnostic developers focused on oncology and immunology.

Application

• Pharmaceutical R&D: Primary reagent for the development of novel antibody-based cancer therapies.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy and mechanism of action.
• Biomarker Research: Essential tool for identifying and validating specific cellular targets in disease pathways.
• Process Development: Serves as a reference standard in upstream and downstream biomanufacturing process optimization.
• Diagnostic Assay Development: Key component in the creation of sensitive immunoassays for clinical diagnostics.
• Academic Research: Supports fundamental research in immunology and cell signaling mechanisms at universities and institutes.

Basic Information

Product Name	Ontuxizumab
CAS No.	946415-62-9
Molecular Formula	Data on file
Molecular Weight	Approx. 150 kDa
Synonyms	MORAb-004; Anti-Endosialin Monoclonal Antibody; Anti-CD248 Antibody; Anti-TEM1 Antibody; Recombinant Humanized Anti-Endosialin IgG1 kappa; Monoclonal Antibody to CD248
EINECS	Not applicable for biopharmaceuticals

Quality Control

Every batch of Ontuxizumab is manufactured under strict quality systems and undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety. Our quality commitment aligns with ICH Q6B guidelines for biotechnological products. A detailed Certificate of Analysis (COA) documenting purity (by SEC-HPLC and CE-SDS), endotoxin levels, sterility, and biological activity is provided with each shipment.

Storage

Preserve in the original container as supplied. For long-term storage, keep frozen at -20°C to -70°C. Avoid repeated freeze-thaw cycles. For short-term use, store at 2-8°C for up to one month. The product is hygroscopic (moisture-sensitive) and light-sensitive; always store in a tightly closed container, protected from light and moisture.

Specification

Item	Specification
Appearance	Clear to slightly opalescent, colorless to pale yellow liquid
Identification (SEC-HPLC / CE-SDS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Concentration	1.0 mg/mL ± 10% (or as specified on COA)
Endotoxin	< 1.0 EU/mg
Sterility	Sterile (Compendial test)
Biological Activity (Binding ELISA / FACS)	≥ 90% relative activity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.