Description

5-Fluoropyridine-2-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluoropyridine moiety enhances biological activity and environmental stability.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for biochemical research.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated bidentate and tridentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Research: A vital reagent for CROs and CDMOs specializing in bespoke fluorinated heterocycle synthesis.

Basic Information

Product Name	5-Fluoropyridine-2-Boronic Acid
CAS No.	946002-10-4
Molecular Formula	C5H5BFNO2
Molecular Weight	140.91 g/mol
Synonyms	(5-Fluoropyridin-2-yl)boronic Acid; 2-Borono-5-fluoropyridine; 5-Fluoro-2-pyridineboronic Acid; 5-Fluoropyridine-2-boronic Acid Pinacol Ester (common derivative); 5-Fluoro-2-pyridinylboronic Acid; 5-F-2-PyB(OH)2; 946002-10-4; 5-Fluoropyridin-2-ylboronic Acid
EINECS	Contact for details

Quality Control

Our 5-Fluoropyridine-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.