Description

5-(2-Fluoropyridin-3-Yl)-2-Methoxybenzaldehyde is a high-purity fluorinated pyridine derivative and a key advanced pharmaceutical intermediate. This compound is valued for its role as a versatile building block in the synthesis of complex, biologically active molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the fluoropyridine moiety for enhanced bioactivity and stability.
• Material Science: Serves as a precursor for functionalized organic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Acts as a versatile aldehyde component in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, for creating complex molecular architectures.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	5-(2-Fluoropyridin-3-Yl)-2-Methoxybenzaldehyde
CAS No.	946001-89-4
Molecular Formula	C13H10FNO2
Molecular Weight	231.22 g/mol
Synonyms	2-Methoxy-5-(2-fluoropyridin-3-yl)benzaldehyde; 5-(2-Fluoro-3-pyridinyl)-2-methoxybenzaldehyde; 2-Fluoro-3-(4-formyl-2-methoxyphenyl)pyridine; 946001-89-4; Benzaldehyde, 5-(2-fluoro-3-pyridinyl)-2-methoxy-; 3-(4-Formyl-2-methoxyphenyl)-2-fluoropyridine
EINECS	Contact for details

Quality Control

Our production of 5-(2-Fluoropyridin-3-Yl)-2-Methoxybenzaldehyde adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced under cGMP-compliant conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.