Description

2-Hydroxy-3-Fluoro-5-Bromotoluene is a halogenated and fluorinated aromatic compound that serves as a versatile and high-value synthetic intermediate. Its unique substitution pattern makes it a critical building block for constructing complex molecular architectures in advanced research and development. This compound is primarily sought after by pharmaceutical, agrochemical, and specialty chemical manufacturers for applications in drug discovery, material science, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogen and fluorine substitution for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the bromo and fluoro groups can significantly influence biological activity.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating novel organic electronic materials and liquid crystal compounds due to its aromatic core and halogen functionalities.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings, enabling the formation of complex biaryl and other structures.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine atoms on aromatic systems and for developing new fluorination methodologies.
• Dye & Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where halogen atoms are integral to the color and stability of the final product.

Basic Information

Product Name	2-Hydroxy-3-Fluoro-5-Bromotoluene
CAS No.	945557-29-9
Molecular Formula	C7H6BrFO
Molecular Weight	205.03 g/mol
Synonyms	3-Bromo-5-fluoro-2-methylphenol; 5-Bromo-3-fluoro-2-methylphenol; 2-Methyl-3-fluoro-5-bromophenol; 3-Fluoro-5-bromo-o-cresol; 2-Hydroxy-3-fluoro-5-bromotoluene; 3-Fluoro-5-bromo-2-hydroxytoluene; 2-Methyl-5-bromo-3-fluorophenol
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Fluoro-5-Bromotoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.