Description

Gsk 189254 is a high-purity, small molecule compound identified by CAS NO 945493-87-8. This product is a valuable research-grade chemical, primarily utilized as a potent and selective pharmacological tool in neuroscience and drug discovery. It is essential for researchers and organizations in the pharmaceutical and biotechnology sectors. Its defined chemical properties make it a critical component for in vitro and in vivo studies targeting specific biological pathways.

Application

• Neuroscience Research: Used as a selective antagonist for studying histamine H3 receptor function and its role in cognitive processes, sleep-wake cycles, and feeding behavior.
• Drug Discovery & Development: Serves as a key reference standard and pharmacological probe in high-throughput screening (HTS) and lead optimization programs for central nervous system (CNS) disorders.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays, and enzyme inhibition tests to elucidate mechanism of action.
• Academic & Institutional Research: Provides a reliable tool for universities and research institutes conducting fundamental research on neurotransmitter systems.
• Preclinical Studies: Utilized in animal models to investigate potential therapeutic efficacy and pharmacokinetic profiles for conditions like narcolepsy, obesity, and attention deficit disorders.

Basic Information

Product Name	Gsk 189254
CAS No.	945493-87-8
Molecular Formula	C19H24N4O
Molecular Weight	324.42 g/mol
Synonyms	1-[(2S,3S)-3-(4-Chlorophenyl)-2-(1H-imidazol-4-ylmethyl)-2-methylbutyl]guanidine; GSK-189254; GSK189254; GSK 189254A; 1-[(2S,3S)-3-(4-Chlorophenyl)-2-[(1H-imidazol-4-yl)methyl]-2-methylbutyl]guanidine; Histamine H3 receptor antagonist GSK189254
EINECS	Contact for details

Quality Control

Our Gsk 189254 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.