Description

3-Difluoromethyl-Benzaldehyde is a high-purity aromatic aldehyde building block featuring a difluoromethyl substituent, a key structural motif in modern synthetic chemistry. This compound is valued for its role in introducing the difluoromethyl group, a bioisostere known to enhance metabolic stability and membrane permeability in target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, antiviral agents, and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoromethyl group improves efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and liquid crystal materials.
• Fluorine Chemistry: An essential reagent for studying structure-activity relationships (SAR) and for introducing fluorine atoms into complex organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production projects.

Basic Information

Product Name	3-Difluoromethyl-Benzaldehyde
CAS No.	945004-44-4
Molecular Formula	C8H6F2O
Molecular Weight	156.13 g/mol
Synonyms	m-Difluoromethylbenzaldehyde; 3-(Difluoromethyl)benzaldehyde; Benzaldehyde, 3-(difluoromethyl)-; 3-DFMB; α,α-Difluoro-m-tolualdehyde; 1-(Difluoromethyl)-3-formylbenzene; 3-Formylbenzylidene difluoride
EINECS	Contact for details

Quality Control

Every batch of 3-Difluoromethyl-Benzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.