Description

4-(Trifluoromethyl)Phenylglyoxal Hydrate is a versatile and highly functionalized aromatic glyoxal derivative. This compound is a critical synthetic intermediate valued for its trifluoromethyl group, which imparts unique electronic and lipophilic properties to target molecules. It is primarily sought after by research chemists and process development teams in the pharmaceutical and agrochemical industries for constructing complex heterocycles and fluorinated bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Chemical Research & Development: Essential reagent in organic synthesis for constructing complex molecular architectures, including fused ring systems and fluorinated heterocycles like imidazoles and quinoxalines.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands and organocatalysts for asymmetric synthesis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable substrate for investigating the influence of the CF3 group on reaction mechanisms and physicochemical properties in medicinal chemistry.

Basic Information

Product Name	4-(Trifluoromethyl)Phenylglyoxal Hydrate
CAS No.	1736-56-7
Molecular Formula	C9H5F3O3
Molecular Weight	218.13 g/mol
Synonyms	α-Oxo-4-(trifluoromethyl)benzeneacetaldehyde Hydrate; 2-Oxo-2-[4-(trifluoromethyl)phenyl]acetaldehyde Hydrate; 4-(Trifluoromethyl)benzoylformaldehyde Hydrate; 4-(Trifluoromethyl)mandelic aldehyde Hydrate; (4-Trifluoromethylphenyl)glyoxal Hydrate; 4-Trifluoromethylphenylglyoxal Monohydrate; p-Trifluoromethylphenylglyoxal Hydrate
EINECS	217-085-4

Quality Control

Our 4-(Trifluoromethyl)Phenylglyoxal Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in cGMP-compliant pharmaceutical development and other high-precision industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure. For long-term storage, consider using desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.