Description

3'-Methyl-2,2,2-Trifluoroacetophenone is a versatile fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoroacetyl group, which is crucial for constructing complex molecules with enhanced properties. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of trifluoromethyl-containing drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the trifluoromethyl group improves biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals with unique optical and electronic properties.
• Chemical Research: A valuable reagent for studying nucleophilic addition and condensation reactions involving activated ketones.
• Custom Synthesis: Provides a foundational structure for contract research organizations (CROs) and CDMOs developing proprietary compounds for clients.

Basic Information

Product Name	3'-Methyl-2,2,2-Trifluoroacetophenone
CAS No.	1736-06-7
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	2,2,2-Trifluoro-1-(3-methylphenyl)ethanone; 1-(3-Methylphenyl)-2,2,2-trifluoroethanone; 3-Methyl-α,α,α-trifluoroacetophenone; m-Methyl-α,α,α-trifluoroacetophenone; 3'-Methyl-α,α,α-trifluoroacetophenone; 3-Methylphenyl trifluoromethyl ketone; 1-(m-Tolyl)-2,2,2-trifluoroethanone
EINECS	217-087-6

Quality Control

Our 3'-Methyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.