Description

5-Trifluoromethyl-Pyrimidine-2-Carboxylic Acid is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a trifluoromethyl group on the pyrimidine ring, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and kinase inhibitor research.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for metal-organic frameworks (MOFs) or catalysts used in fine chemical processes.
• Material Science Precursor: Acts as a monomer or functionalizing agent for creating specialty polymers and advanced materials with specific electronic or surface properties.
• Chemical Biology Probe Synthesis: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	5-Trifluoromethyl-Pyrimidine-2-Carboxylic Acid
CAS No.	944905-44-6
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	2-Pyrimidinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)pyrimidine-2-carboxylic acid; 5-Trifluoromethyl-2-pyrimidinecarboxylic acid; 5-Trifluoromethylpyrimidine-2-carboxylic acid; 944905-44-6; AI3-32043
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethyl-Pyrimidine-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, handle with appropriate engineering controls.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.