Description

2-(2,2,2-Trifluoroethoxy)Pyrimidine-5-Carboxylic Acid is a high-purity fluorinated pyrimidine derivative, a critical building block in modern pharmaceutical and agrochemical research. Its unique trifluoroethoxy substituent imparts desirable metabolic stability and lipophilicity, making it a valuable intermediate for developing active ingredients. This compound is essential for R&D chemists and process development scientists in the life sciences sector, particularly those working on novel small-molecule therapeutics and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology, antiviral, and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine moiety enhances biological activity and environmental persistence.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in synthesizing specialty polymers and liquid crystals that require fluorinated aromatic components for specific electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Pyrimidine-5-Carboxylic Acid
CAS No.	944905-08-2
Molecular Formula	C7H5F3N2O3
Molecular Weight	222.12 g/mol
Synonyms	5-Carboxy-2-(2,2,2-trifluoroethoxy)pyrimidine; 2-(Trifluoroethoxy)pyrimidine-5-carboxylic acid; Pyrimidine-5-carboxylic acid, 2-(2,2,2-trifluoroethoxy)-; 944905-08-2; 2-Trifluoroethoxypyrimidine-5-carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(2,2,2-Trifluoroethoxy)Pyrimidine-5-Carboxylic Acid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.