Description

2-Amino-5-(Trifluoromethyl)Nicotinaldehyde is a high-value, multi-functional chemical building block characterized by its reactive aldehyde and amino groups on a nicotinic acid-derived heterocyclic core. This compound matters for its critical role in facilitating the synthesis of complex nitrogen-containing heterocycles, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors, antiviral agents, and other nitrogen-rich bioactive molecules.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags, enzyme inhibitors, and other molecular probes for biological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring specialized pyridine derivatives.

Basic Information

Product Name	2-Amino-5-(Trifluoromethyl)Nicotinaldehyde
CAS No.	944904-70-5
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	5-(Trifluoromethyl)-2-aminonicotinaldehyde; 2-Amino-5-(trifluoromethyl)pyridine-3-carboxaldehyde; 3-Formyl-5-(trifluoromethyl)pyridin-2-amine; 2-Amino-3-formyl-5-(trifluoromethyl)pyridine; 5-Trifluoromethyl-2-aminonicotinaldehyde; Aldehyde derivative of 2-amino-5-(trifluoromethyl)pyridine; 2-Amino-5-trifluoromethylnicotinaldehyde
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(Trifluoromethyl)Nicotinaldehyde is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.