Description

3-Chloromethyl-2-Methoxy-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a reactive chloromethyl group and a trifluoromethyl moiety, makes it indispensable for introducing specific molecular fragments to enhance the properties of target compounds. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its incorporation can improve metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Chloromethyl-2-Methoxy-5-(Trifluoromethyl)Pyridine
CAS No.	944904-67-0
Molecular Formula	C8H7ClF3NO
Molecular Weight	225.59 g/mol
Synonyms	2-Methoxy-5-(trifluoromethyl)-3-pyridinemethanol chloride; 3-(Chloromethyl)-2-methoxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-methoxypyridin-3-ylmethyl chloride; 2-Methoxy-3-chloromethyl-5-trifluoromethylpyridine; 3-Pyridinemethanol, 2-methoxy-5-(trifluoromethyl)-, chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloromethyl-2-Methoxy-5-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by validated methods (HPLC, GC, NMR) is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to the compound's sensitivity to moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.