Description

(5-(Trifluoromethyl)-2-Methoxypyridin-3-Yl)Methanamine is a high-value pyridine derivative and a versatile trifluoromethylated building block for advanced organic synthesis. Its unique structure, combining a methoxy group and a trifluoromethyl group on the pyridine ring with a reactive primary amine, makes it a critical intermediate for creating novel compounds with enhanced properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. Its application is essential for developing new active ingredients with improved metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or organic semiconductors, where its electronic properties are valuable.
• Custom Synthesis and Contract Manufacturing: A crucial starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Chemical Biology & Proteomics: Can be used to create chemical probes for studying biological pathways and protein function.

Basic Information

Product Name	(5-(Trifluoromethyl)-2-Methoxypyridin-3-Yl)Methanamine
CAS No.	944904-64-7
Molecular Formula	C8H9F3N2O
Molecular Weight	206.17 g/mol
Synonyms	3-(Aminomethyl)-5-(trifluoromethyl)-2-methoxypyridine; 2-Methoxy-5-(trifluoromethyl)-3-pyridinemethanamine; (5-Trifluoromethyl-2-methoxy-pyridin-3-yl)-methylamine; 3-Pyridinemethanamine, 2-methoxy-5-(trifluoromethyl)-; 2-Methoxy-5-(trifluoromethyl)nicotinylamine
EINECS	Contact for details

Quality Control

Our (5-(Trifluoromethyl)-2-Methoxypyridin-3-Yl)Methanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliable supply for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.