Description

1-(6-Trifluoromethyl-Pyridin-2-Yl)-Ethanone is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, which is highly sought after for modifying molecular characteristics. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides, where the CF3 group improves lipophilicity and biological activity.
• Material Science Research: Used in the development of specialty chemicals, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and enzyme inhibitors in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	1-(6-Trifluoromethyl-Pyridin-2-Yl)-Ethanone
CAS No.	944904-58-9
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	2-Acetyl-6-(trifluoromethyl)pyridine; 1-[6-(Trifluoromethyl)pyridin-2-yl]ethanone; 6-(Trifluoromethyl)-2-acetylpyridine; Ethanone, 1-[6-(trifluoromethyl)-2-pyridinyl]-; 2-Pyridinyl, 6-(trifluoromethyl)-, ethanone derivative
EINECS	Contact for details

Quality Control

Our 1-(6-Trifluoromethyl-Pyridin-2-Yl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light), as indicated in its chemical properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.