Description

2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene CAS NO 944901-07-9 is a high-value, multi-functional aromatic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications in cross-coupling reactions and as a key intermediate in active ingredient synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the bromine atom facilitates further functionalization via metal-catalyzed cross-coupling reactions.
• Material Science Research: Acts as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials that benefit from the unique properties of fluorine.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings, allowing for the efficient construction of complex biaryl structures common in many functional molecules.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and tags for studying biological systems, leveraging its reactive bromine handle for bioconjugation.

Basic Information

Item	Information
Product Name	2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene
CAS No.	944901-07-9
Molecular Formula	C9H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	1-Bromo-2-Methoxy-5-(Trifluoromethyl)Benzene; 2-Bromo-4-Methoxybenzotrifluoride; 2-Bromo-α,α,α-Trifluoro-p-Anisole; 5-Bromo-2-Methoxybenzotrifluoride; 4-Methoxy-2-Bromobenzotrifluoride; 2-Bromo-4-Methoxy-α,α,α-Trifluorotoluene; 2-Bromo-4-Methoxy-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to verify identity and quantify purity and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.