Description

5-Amino-2-Trifluoromethyl-Isonicotinic Acid CAS NO 944900-27-0 is a high-purity, multifunctional heterocyclic building block featuring both an amino group and a carboxylic acid moiety on a fluorinated pyridine core. This compound is valued for its unique trifluoromethyl group, which imparts enhanced metabolic stability and lipophilicity, making it a critical intermediate in advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Key pharmaceutical intermediate for the synthesis of small molecule drugs, particularly kinase inhibitors and other targeted therapies.
• Building block in agrochemical research for developing new herbicides and fungicides with improved efficacy.
• Versatile precursor for custom synthesis and contract manufacturing of fluorinated specialty chemicals.
• Used in material science research for creating advanced polymers and ligands with specific electronic properties.
• Intermediate in the development of diagnostic agents and imaging probes due to the favorable properties of the fluorine atoms.

Basic Information

Product Name	5-Amino-2-Trifluoromethyl-Isonicotinic Acid
CAS No.	944900-27-0
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	5-Amino-2-(trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 5-amino-2-(trifluoromethyl)-; 2-Trifluoromethyl-5-amino-isonicotinic acid; 5-Amino-2-trifluoromethyl-isonicotinic acid; 5-Amino-2-(trifluoromethyl)isonicotinic acid; ATFIA
EINECS	Contact for details

Quality Control

Our production of 5-Amino-2-Trifluoromethyl-Isonicotinic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for advanced applications and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.