Description

6-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride group and electron-withdrawing trifluoromethyl substituent. This compound matters for its critical role in facilitating the synthesis of complex molecules, particularly in the development of advanced agrochemicals and pharmaceuticals where the introduction of a sulfonamide moiety is required. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries seeking to build novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides that benefit from the metabolic stability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzymes.
• Custom Synthesis & Contract Manufacturing: A vital reagent for CROs and CDMOs engaged in the custom production of complex, fluorinated organic molecules.

Basic Information

Product Name	6-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride
CAS No.	944900-24-7
Molecular Formula	C6H3ClF3NO2S
Molecular Weight	245.61 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-2-pyridinesulfonyl chloride; 6-(Trifluoromethyl)pyridine-2-sulfonyl chloride; 2,6-Bis(trifluoromethyl)pyridine-3-sulfonyl chloride (related isomer); 6-Trifluoromethylpyridine-2-sulfonyl chloride; 2-Sulfonylchloride-6-trifluoromethylpyridine; 944900-24-7; 6-CF3-Py-2-SO2Cl
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)Pyridine-2-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and GC-MS, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.