Description

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated pyridine motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides, facilitating carbon-carbon bond formation.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage the biological activity of fluorinated heterocycles.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating complex nitrogen-containing ligands used in homogeneous catalysis.
• Material Science: Employed in the research and development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Utilized as a molecular probe or tag in bioconjugation strategies due to its reactive handles.

Basic Information

Product Name	3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	944401-75-6
Molecular Formula	C11H16BFN2O2
Molecular Weight	238.07 g/mol
Synonyms	2-Amino-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 2-Pyridinamine, 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Fluoro-5-(pinacolatoboryl)pyridin-2-amine; 2-Amino-3-fluoro-5-(pinacolatoboryl)pyridine; 5-(Pinacolatoboraneyl)-3-fluoropyridin-2-amine; 944401-75-6; Boronic acid, B-(6-amino-5-fluoro-3-pyridinyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to maximize shelf life due to the light-sensitive and potentially moisture-sensitive nature of boronic esters.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.