Description

6-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating novel, fluorinated herbicides, fungicides, and insecticides with enhanced biological activity and environmental stability.
• Material Science Research: Serves as a building block for developing organic electronic materials, such as OLEDs and semiconductors, where the pyridine and boronate functionalities are advantageous.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for diagnostic assays and biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & R&D Laboratories: Used extensively in university and industrial R&D for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Item	Details
Product Name	6-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	944401-71-2
Molecular Formula	C11H16BFN2O2
Molecular Weight	238.07 g/mol
Synonyms	2-Amino-6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoropyridin-2-amine; 2-Pyridinamine, 6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-Fluoro-5-(pinacolatoboron)pyridin-2-amine; 2-Amino-6-fluoro-5-(pinacolatoboron)pyridine; 5-(Pinacolatoboran-2-yl)-6-fluoropyridin-2-amine
EINECS	Contact for details

Quality Control

Our 6-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.