Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Pyridin-2-Amine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to introduce the 4-(trifluoromethyl)pyridin-2-amine pharmacophore into complex target molecules.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that incorporate the trifluoromethylpyridine moiety for enhanced bioactivity and environmental stability.
• Material Science Research: Used in the creation of organic electronic materials, such as ligands for OLEDs and charge-transport materials, due to its electron-deficient pyridine core.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and enzyme inhibitors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to construct biaryl and heterobiaryl structures prevalent in modern chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity boronic ester intermediates.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Pyridin-2-Amine
CAS No.	944401-57-4
Molecular Formula	C12H16BF3N2O2
Molecular Weight	288.08 g/mol
Synonyms	4-(Trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 2-Amino-4-(trifluoromethyl)pyridine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine; 4-Trifluoromethyl-2-amino-5-pyridineboronic acid pinacol ester; 944401-57-4; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.