Description

(2-(Difluoromethoxy)Pyridin-4-Yl)Methanamine is a high-value pyridine derivative featuring a difluoromethoxy substituent, serving as a critical building block in advanced organic synthesis. Its unique fluorinated structure is essential for modulating the physicochemical and metabolic properties of target molecules, enhancing their potency and bioavailability. This intermediate is primarily sought by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group can improve efficacy and environmental profile.
• Chemical Biology & Proteomics: Employed as a versatile linker or functional handle in the design of molecular probes and biochemical tools.
• Material Science Research: Investigated as a precursor for specialty polymers and liquid crystals where fluorine incorporation alters material properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in multi-step synthetic routes for client-specific molecules.

Basic Information

Product Name	(2-(Difluoromethoxy)Pyridin-4-Yl)Methanamine
CAS No.	943894-77-7
Molecular Formula	C7H8F2N2O
Molecular Weight	174.15 g/mol
Synonyms	4-(Aminomethyl)-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-4-pyridinemethanamine; 4-(Aminomethyl)-2-(difluoromethoxy)pyridine; (2-(Difluoromethoxy)-4-pyridinyl)methanamine; 1-(2-(Difluoromethoxy)pyridin-4-yl)methanamine; 4-Pyridinemethanamine, 2-(difluoromethoxy)-; 2-Difluoromethoxy-pyridin-4-ylmethylamine
EINECS	Contact for details

Quality Control

Every batch of (2-(Difluoromethoxy)Pyridin-4-Yl)Methanamine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.