Description

Tigilanol Tiglate is a novel, first-in-class small molecule oncolytic agent with a unique mechanism of action. This compound is of significant interest for its ability to induce rapid and immunogenic tumor cell death, leading to localized tumor ablation and systemic immune activation. It is primarily utilized by pharmaceutical researchers and developers in the oncology and immunotherapy sectors for drug discovery, preclinical studies, and clinical development programs.

Application

• Oncolytic Drug Development: Core active pharmaceutical ingredient (API) for novel cancer therapeutics.
• Preclinical Cancer Research: Used in in vitro and in vivo studies to investigate mechanisms of immunogenic cell death.
• Veterinary Oncology: Key component in approved treatments for non-metastatic, injectable tumors in dogs (e.g., mast cell tumors).
• Immunotherapy Combinations: Research into synergistic effects with checkpoint inhibitors and other immunomodulators.
• Formulation Studies: Development of stable injectable formulations and drug delivery systems.
• Mechanistic Studies: Tool compound for studying protein kinase C (PKC) signaling and tumor vasculature disruption.

Basic Information

Product Name	Tigilanol Tiglate
CAS No.	943001-56-7
Molecular Formula	C34H50O8
Molecular Weight	586.76 g/mol
Synonyms	EBC-46; TTG; STG; Tigilanol tiglate; 3-(2-Methylbutanoyl)-13-(2-methylbut-2-enoyl)-12,20-dihydroxy-1,7,10-tris(2-methylbutanoyloxy)-4,9-dioxo-11,15-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-13(18),14,16-triene-5,16-dione; [1R-(1R*,4E,7S*,9S*,10R*,12R*,13R*,14E,18S*)]-13-[(2E)-2-Methyl-2-butenoyl]oxy-12,20-dihydroxy-3,7,10-tris(2-methyl-1-oxobutoxy)-4,9-dioxo-11,15-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-4,14-diene-5,16-dione
EINECS	Contact for details

Quality Control

Our Tigilanol Tiglate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the Certificate of Analysis. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.