Description

Pf-03814735 is a high-purity, small-molecule chemical compound identified by CAS NO 942487-16-3. This compound is a potent and selective inhibitor of the Aurora kinase family, specifically targeting Aurora A and B kinases, which are critical regulators of cell cycle progression and mitosis. It is primarily utilized by pharmaceutical researchers and development scientists in the fields of oncology and cell biology for drug discovery, target validation, and biochemical assay development.

Application

• Oncology Research: Used as a key biochemical tool to study the role of Aurora kinases in tumor cell proliferation, apoptosis, and chemoresistance.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel anti-cancer therapeutics targeting mitotic pathways.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro kinase inhibition assays to evaluate the potency and selectivity of new drug candidates.
• Cell Biology Studies: Facilitates research into cell cycle regulation, mitotic spindle formation, and chromosome segregation in various cell lines.
• Preclinical Studies: Utilized in animal models to investigate the pharmacokinetics, pharmacodynamics, and efficacy of Aurora kinase inhibition.

Basic Information

Product Name	Pf-03814735
CAS No.	942487-16-3
Molecular Formula	C₂₁H₂₀FN₅O₂
Molecular Weight	393.42 g/mol
Synonyms	PF 03814735; PF-03814735; Aurora Kinase Inhibitor PF-03814735; 2-[(2R,5S)-5-[(5-Fluoro-2-oxo-1H-pyrimidin-1-yl)methyl]-2-methyl-1,3-oxazolidin-3-yl]-N-(5-methyl-1H-pyrazol-3-yl)acetamide; UNII-4F0Y1J3G4N; 4F0Y1J3G4N
EINECS	Contact for details

Quality Control

Our Pf-03814735 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.