Description

2',4'-Difluoro-Biphenyl-4-Sulfonyl Chloride is a high-purity, multi-functional sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its reactive sulfonyl chloride group, which enables efficient introduction of the sulfonyl moiety into complex molecular architectures under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to create novel sulfonylurea or sulfonamide herbicides and fungicides with enhanced activity.
• Material Science: Building block for synthesizing specialty monomers and polymers, such as sulfonated poly(arylene ether sulfone)s for membrane applications.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzymes.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for the custom synthesis of complex, fluorinated biphenyl derivatives for various R&D projects.

Basic Information

Product Name	2',4'-Difluoro-Biphenyl-4-Sulfonyl Chloride
CAS No.	942475-01-6
Molecular Formula	C12H7ClF2O2S
Molecular Weight	288.70 g/mol
Synonyms	4-(2,4-Difluorophenyl)benzenesulfonyl chloride; 2,4-Difluorobiphenyl-4'-sulfonyl chloride; (2,4-Difluoro[1,1'-biphenyl]-4-yl)sulfonyl chloride; 1,1'-Biphenyl, 2',4'-difluoro-4-sulfonylchloride; Biphenyl-4-sulfonyl chloride, 2',4'-difluoro-; 2',4'-Difluoro[1,1'-biphenyl]-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2',4'-Difluoro-Biphenyl-4-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.