Description

2'-Fluoro-Biphenyl-3-Sulfonyl Chloride is a high-purity, specialized organic intermediate featuring a reactive sulfonyl chloride group and a fluorinated biphenyl backbone. This compound is critically important for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing sulfonamide-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor for the synthesis of novel sulfonamide-based drug candidates, including kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides where the biphenyl-sulfonamide structure confers specific biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic frameworks.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and labeling reagents for proteomics and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2'-Fluoro-Biphenyl-3-Sulfonyl Chloride
CAS No.	942475-00-5
Molecular Formula	C₁₃H₈ClFO₂S
Molecular Weight	282.72 g/mol
Synonyms	2'-Fluorobiphenyl-3-sulfonyl chloride; 3-(2-Fluorophenyl)benzenesulfonyl chloride; 1-(2-Fluorophenyl)-3-(chlorosulfonyl)benzene; 2-Fluoro-3'-sulfonylchlorobiphenyl; [1,1'-Biphenyl]-3-sulfonyl chloride, 2'-fluoro-; Biphenyl-3-sulfonyl chloride, 2'-fluoro derivative; 2-Fluoro-3'-(chlorosulfonyl)biphenyl
EINECS	Contact for details

Quality Control

Every batch of 2'-Fluoro-Biphenyl-3-Sulfonyl Chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed control of related substances. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.