Description

4-Cyano-3-(trifluoromethyl)benzene-1-sulfonyl chloride is a high-value, multi-functional chemical intermediate essential for advanced synthesis. Its unique structure, featuring both a reactive sulfonyl chloride group and a cyano substituent on a trifluoromethylated benzene ring, makes it a critical building block for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and anti-inflammatory drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and cyano groups enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced functional materials.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel ligands for catalysis and molecular recognition.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments, leveraging the electron-withdrawing groups to modify color and lightfastness properties.
• Chemical Biology Probe Synthesis: Acts as a versatile handle for bioconjugation and the creation of activity-based probes for proteomics and diagnostic research.

Basic Information

Product Name	4-Cyano-3-(trifluoromethyl)benzene-1-sulfonyl chloride
CAS No.	942199-59-9
Molecular Formula	C8H3ClF3NO2S
Molecular Weight	269.62 g/mol
Synonyms	2-Cyano-α,α,α-trifluoro-p-toluenesulfonyl chloride; 4-Cyano-α,α,α-trifluoro-m-toluenesulfonyl chloride; 2-Cyano-α,α,α-trifluoro-4-methylbenzenesulfonyl chloride; 3-(Trifluoromethyl)-4-cyanobenzenesulfonyl chloride; 4-Cyano-3-trifluoromethylbenzenesulfonyl chloride; 2-Cyano-4-(trifluoromethyl)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-cyano-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Cyano-3-(trifluoromethyl)benzene-1-sulfonyl chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.