Description

4-Chloro-3-Fluorobenzenesulfonyl Chloride is a versatile and high-purity sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its dual functionality as an electrophilic sulfonylation reagent and a precursor for sulfonamide formation, enabling the creation of complex molecules with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides that require the sulfonyl moiety for bioactivity.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers, membranes, and functional coatings.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new reaction pathways and creating compound libraries.
• Dye and Pigment Manufacturing: Intermediate for synthesizing sulfonated dyes and colorants with enhanced solubility and fastness properties.

Basic Information

Product Name	4-Chloro-3-Fluorobenzenesulfonyl Chloride
CAS No.	942035-77-0
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.06 g/mol
Synonyms	4-Chloro-3-fluorobenzene-1-sulfonyl chloride; 3-Fluoro-4-chlorobenzenesulfonyl chloride; 1-Chloro-4-(chlorosulfonyl)-2-fluorobenzene; Benzenesulfonyl chloride, 4-chloro-3-fluoro-; 2-Fluoro-4-chlorobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-Fluorobenzenesulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all test results are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.