Description

2-Fluoro-5-Hydrazinylpyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the juxtaposition of fluorine and hydrazine substituents, enabling the construction of complex nitrogen-containing heterocycles. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A valuable reagent for medicinal chemistry programs and the exploration of new chemical space in drug discovery.
• Fluorinated Compound Libraries: Used to introduce fluorine atoms into compound libraries for screening, as fluorination is a common strategy to modulate bioavailability and metabolic stability.
• Heterocyclic Chemistry: Fundamental building block for constructing complex fused-ring systems like pyrazolo[3,4-b]pyridines and other nitrogen-rich heterocycles.

Basic Information

Item	Details
Product Name	2-Fluoro-5-Hydrazinylpyridine
CAS No.	940958-93-0
Molecular Formula	C5H6FN3
Molecular Weight	127.12 g/mol
Synonyms	5-Hydrazinyl-2-fluoropyridine; 2-Fluoro-5-hydroxylaminopyridine (related); 2-Fluoropyridin-5-amine, N-aminohydrazone derivative; 2-Fluoro-5-hydrozinylpyridine; 2-Fluoro-5-hydrazinopyridine; 5-Hydrazino-2-fluoropyridine; 2-Fluoropyridine-5-hydrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Hydrazinylpyridine is produced and tested under strict quality management protocols to ensure consistency and purity for demanding R&D and scale-up applications. Our standard grade meets high-purity specifications suitable for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and propensity to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. For long-term stability, storage at 2-8°C is advised.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.