Description

5-Chloro-3-Fluoro-2-Iodotoluene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and iodine substituents on a toluene backbone, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the specific halogen pattern can influence bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials that benefit from halogenated aromatic units.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide excellent handles for versatile metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Negishi) to form complex biaryl and other structures.
• Chemical Library Development: Employed in parallel and combinatorial synthesis for generating diverse compound libraries for high-throughput screening in drug discovery.
• Fluorine Chemistry Studies: Acts as a valuable substrate for studying the effects of fluorine substitution on the reactivity and physical properties of aromatic systems.

Basic Information

Product Name	5-Chloro-3-Fluoro-2-Iodotoluene
CAS No.	939990-13-3
Molecular Formula	C7H5ClFI
Molecular Weight	269.47 g/mol
Synonyms	1-Chloro-3-fluoro-2-iodo-5-methylbenzene; 2-Iodo-5-chloro-3-fluorotoluene; 3-Fluoro-5-chloro-2-iodotoluene; Toluene, 5-chloro-3-fluoro-2-iodo-; 5-Chloro-3-fluoro-2-iodo-1-methylbenzene; 2-Chloro-6-fluoro-3-iodotoluene (alternative numbering)
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Fluoro-2-Iodotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC/GC), identity confirmation (by IR/NMR), and impurity profiles. Our quality commitment ensures material integrity for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storage under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Single Maximum Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.