Description

Pf-562271 is a potent and selective small molecule inhibitor of Focal Adhesion Kinase (FAK), a key signaling protein involved in cell adhesion, migration, and survival. This compound is a critical research tool for investigating FAK's role in cancer biology, tumor metastasis, and cellular mechanotransduction pathways. It is essential for pharmaceutical R&D, academic research, and biotechnology laboratories focused on oncology target validation and preclinical drug discovery.

Application

• Biochemical Research: Used as a selective FAK inhibitor to study signal transduction pathways in cell adhesion, proliferation, and survival.
• Oncology Research: A vital tool for investigating the role of FAK in tumor growth, angiogenesis, and metastasis in various cancer cell lines and animal models.
• Drug Discovery & Development: Serves as a reference compound and pharmacological probe for screening and developing novel anti-cancer therapeutics targeting FAK.
• Cellular Mechanobiology Studies: Employed to dissect the function of FAK in cellular responses to mechanical forces and extracellular matrix interactions.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in cell biology and cancer pathology.

Basic Information

Product Name	Pf-562271
CAS No.	939791-38-5
Molecular Formula	C30H30N8O3
Molecular Weight	550.61 g/mol
Synonyms	PF562271; PF 562271; N-Methyl-4-[[(7-oxo-6,7-dihydro-8H-pyrido[2,3-d]pyrimidin-4-yl)amino]methyl]-N-[3-(trifluoromethyl)phenyl]benzamide; FAK Inhibitor PF-562271; Benzamide, N-methyl-4-[[(7-oxo-6,7-dihydro-8H-pyrido[2,3-d]pyrimidin-4-yl)amino]methyl]-N-[3-(trifluoromethyl)phenyl]-; VS-4718 (developmental code)
EINECS	Contact for details

Quality Control

Our Pf-562271 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.