Description

3'-Fluoro-Biphenyl-4-Sulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. Its core value lies in the versatile sulfonyl chloride functional group, which enables efficient derivatization into sulfonamides and sulfonate esters under mild conditions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting kinase inhibition and G-protein-coupled receptors (GPCRs).
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the biphenyl core provides structural stability.
• Material Science Research: Serves as a precursor for functionalized polymers and liquid crystals, leveraging its aromatic and sulfonyl groups.
• Chemical Biology Probes: Employed in creating activity-based probes (ABPs) and affinity tags for studying enzyme function and protein labeling.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs specializing in bespoke organic molecules for client projects.
• Sulfonamide Library Production: Facilitates high-throughput parallel synthesis for medicinal chemistry and screening libraries.

Basic Information

Product Name	3'-Fluoro-Biphenyl-4-Sulfonyl Chloride
CAS No.	939761-07-6
Molecular Formula	C12H8ClFO2S
Molecular Weight	270.70 g/mol
Synonyms	4-(3-Fluorophenyl)benzenesulfonyl chloride; [1,1'-Biphenyl]-4-sulfonyl chloride, 3'-fluoro-; 3'-Fluorobiphenyl-4-sulfonyl chloride; 3-Fluoro-4'-sulfonylchloridobiphenyl; (3-Fluorophenyl)(4-sulfonylchloride)benzene; 4-(3-Fluorobiphenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-Biphenyl-4-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.