Description

Ku-0063794 is a potent, selective, and ATP-competitive inhibitor of the mammalian target of rapamycin (mTOR) kinase. This compound is crucial for biochemical research as it specifically targets the mTORC1 and mTORC2 complexes, enabling precise study of the PI3K/Akt/mTOR signaling pathway. Researchers in oncology, metabolic disease, and cell biology rely on Ku-0063794 CAS NO 938440-64-3 for investigating cell growth, proliferation, and survival mechanisms.

Application

• Biochemical Research: A key tool for selectively inhibiting mTOR kinase activity in cell-based assays and in vitro studies.
• Oncology Research: Used to study the role of mTOR signaling in cancer cell proliferation, tumor growth, and resistance mechanisms.
• Signal Transduction Studies: Essential for dissecting the PI3K/Akt/mTOR pathway and its cross-talk with other cellular pathways.
• Metabolic Disease Research: Applied in models to understand mTOR's function in nutrient sensing, autophagy, and metabolic regulation.
• Neurobiology: Utilized in research on neuronal development, synaptic plasticity, and neurodegenerative conditions linked to mTOR signaling.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing novel mTOR-targeted therapeutic agents.

Basic Information

Product Name	Ku-0063794
CAS No.	938440-64-3
Molecular Formula	C₂₃H₂₃N₅O₃
Molecular Weight	417.46 g/mol
Synonyms	Ku-0063794; KU0063794; 4-[4-(1-Aminocyclobutyl)phenyl]-2-(4-morpholin-4-ylphenyl)pyrido[2,3-d]pyrimidin-7-one; mTOR Kinase Inhibitor, Ku-0063794; mTOR Inhibitor V; mTORC1/mTORC2 Inhibitor
EINECS	Contact for details

Quality Control

Our Ku-0063794 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.