Description

Osi-027 CAS NO 936890-98-1 is a potent and selective small-molecule inhibitor of the mammalian target of rapamycin (mTOR) kinase, specifically targeting the mTORC1 complex. This compound is a critical research tool for studying the PI3K/Akt/mTOR signaling pathway, which is central to cell growth, proliferation, and survival. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, metabolic disease, and aging research, where precise pathway modulation is essential for target validation and drug discovery efforts.

Application

• Biomedical Research: A key reagent for investigating the molecular mechanisms of the mTOR pathway in cell culture and preclinical models.
• Oncology Studies: Used to explore the role of mTORC1 signaling in tumorigenesis, cancer cell proliferation, and resistance to therapy.
• Metabolic Disorder Research: Applied in studies related to insulin signaling, nutrient sensing, and conditions like diabetes and obesity.
• Neurobiology: Employed in research on neurodegenerative diseases and synaptic plasticity where mTOR signaling is implicated.
• Anti-aging and Longevity Research: Utilized to study the effects of mTOR inhibition on lifespan and age-related physiological decline.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing novel mTOR inhibitors.

Basic Information

Product Name	Osi-027
CAS No.	936890-98-1
Molecular Formula	C₂₃H₂₅N₅O₃
Molecular Weight	419.48 g/mol
Synonyms	OSI-027; 8-(6-Methoxy-1H-benzimidazol-2-yl)-2-morpholin-4-ylquinolin-4(1H)-one; AZD-8055 analog; mTORC1/mTORC2 Inhibitor; mTOR Kinase Inhibitor OSI-027
EINECS	Contact for details

Quality Control

Our Osi-027 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications for consistent, reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.