Description

Tubulysin M CAS NO 936691-46-2 is a highly potent synthetic derivative of the natural tubulysin family of cytotoxic peptides. This compound is valued for its exceptional ability to disrupt microtubule dynamics, leading to potent antiproliferative effects in targeted cells. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and targeted drug delivery for the synthesis of advanced antibody-drug conjugates (ADCs) and other bioconjugates.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly cytotoxic warhead in the development of next-generation ADCs for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies investigating novel chemotherapeutic mechanisms.
• Bioconjugation Chemistry: Employed in the synthesis of peptide-drug conjugates and other targeted therapeutic constructs due to its potent bioactivity.
• Mechanistic Studies: A critical tool for studying microtubule inhibition, cell cycle arrest, and apoptosis in various cancer cell lines.
• Drug Discovery Pipeline: Integrated into high-throughput screening and lead optimization programs for novel anticancer agents.

Basic Information

Product Name	Tubulysin M
CAS No.	936691-46-2
Molecular Formula	C45H67N5O10S
Molecular Weight	870.11 g/mol
Synonyms	Tubulysin M; (2S,4R)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-5-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]pentanoic acid; Tubugis M; TUB M
EINECS	Contact for details

Quality Control

Our Tubulysin M is manufactured under strict quality management systems to ensure the highest standards of purity and consistency required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.