Description

3-Ethynyl-5-Fluoropyridin-2-Amine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both an ethynyl group and a fluorinated pyridine core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic semiconductors.
• Chemical Biology Probe: Employed in the design of molecular probes and tags, utilizing the alkyne group for bioorthogonal "click chemistry" conjugation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Item	Details
Product Name	3-Ethynyl-5-Fluoropyridin-2-Amine
CAS No.	936344-74-0
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	2-Amino-3-ethynyl-5-fluoropyridine; 5-Fluoro-3-ethynylpyridin-2-amine; 3-Ethynyl-5-fluoro-2-pyridinamine; 936344-74-0; 5-Fluoro-2-amino-3-ethynylpyridine; 3-Ethynyl-5-fluoropyridin-2-ylamine
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-5-Fluoropyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring stringent material consistency for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.